survivin基因与肿瘤放化疗的敏感性及相关基因治疗

研究显示调亡抑制蛋白survivin与肿瘤放化疗抵抗密切相关,可通过对survivin基因的修饰,抑制survivin基因的表达,使其丧失凋亡抑制功能,从而增加肿瘤的自发性凋亡及放化疗诱发的凋亡,抑制肿瘤生长,提高肿瘤对放化疗的敏感性.

Survivin gene and radio-and chemo-therapy sensitization in cancer and relative genetic therapy

Researches show the intimate relationship between survivin and radio-and chemo-therapy sensitization in cancer. The repression of survivin by gene modifying may make it to lose the ability of inhibiting apoptosis, increasing spontaneous apoptosis and radio-and chemo-therapy induced apoptosis, attenuating tumor proliferation, and enhancing the sensitivities of cancer cells to radoitherpy and chemotherapy.