Midlife predictors of Alzheimer's disease |
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| Authors: | B.B. Bendlin C.M. Carlsson C.E. Gleason S.C. Johnson A. Sodhi C.L. Gallagher L. Puglielli C.D. Engelman M.L. Ries G. Xu W. Wharton S. Asthana |
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| Affiliation: | 1. William S. Middleton Memorial Veterans Hospital, Geriatric Research Educational and Clinical Center, Madison, WI, USA;2. University of Wisconsin School of Medicine and Public Health, Department of Medicine, Madison, WI, USA;3. University of Wisconsin School of Medicine and Public Health, Department of Population Health Sciences, Madison, WI, USA |
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| Abstract: | Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife. |
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| Keywords: | Alzheimer's disease Dementia Midlife Genes Family history Estrogen Vascular risk Education MRI |
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