Variability of biomarkers in volunteer studies: The biological component |
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| Authors: | Suzanne Spaan Wouter Fransman Nick Warren Richard Cotton John Cocker Erik Tielemans |
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| Affiliation: | 1. Business Unit Quality and Safety (Q&S), Department Research & Development, TNO, Zeist, The Netherlands;2. Health and Safety Laboratory (HSL), Harpur Hill, Buxton, Derbyshire SK17 9JN, UK |
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| Abstract: | Biological monitoring has become one of the methods to measure exposure, with the advantage that it gives information about the concentration of a substance that actually enters the body and reflects the inter-individual differences in uptake and metabolic variation. However, limited information is available on inter- and intra-individual variability of biomarkers. The aim of this study was to gather information about the biological component of inter-individual variation in biomarkers using results from volunteer studies. |
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| Keywords: | Biomarkers Intra- and inter-individual variability Volunteer studies |
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