Intracellular distribution,geno- and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells |
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| Authors: | Stephan Hackenberg Gudrun FriehsKatrin Froelich Christian GinzkeyChristian Koehler Agmal ScherzedMarc Burghartz Rudolf HagenNorbert Kleinsasser |
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| Affiliation: | Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany |
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| Abstract: | Nanomaterials are defined as substances with at least one dimension smaller than 100 nm in size and are used for a multitude of purposes. Titanium dioxide nanoparticles (TiO2-NPs) are an important material used as an additive in pharmaceutical and cosmetic products. Due to their high surface-to-mass index, TiO2 nanoparticles show different physical and chemical characteristics compared to the bulk substance. The knowledge about geno- or cytotoxic effects of TiO2-NPs is incomplete since existing studies show contrary results. |
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| Keywords: | Nanoparticles Titanium dioxide Comet assay Human nasal epithelial cells Toxicity |
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