The effects of MAPK inhibitors on a proteasome inhibitor,MG132-induced HeLa cell death in relation to reactive oxygen species and glutathione |
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| Authors: | Yong Hwan Han Woo Hyun Park |
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| Affiliation: | Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, san 2-20 Geumam-dong, Deokjin-gu, JeonJu, 561-180, Republic of Korea |
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| Abstract: | |
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| Keywords: | MG132, carbobenzoxy-Leu-Leu-leucinal ROS, reactive oxygen species MAPK, mitogen-activated protein kinase MEK, MAP kinase or ERK kinase ERK, extracellular signal-regulated kinase JNK, c-Jun N-terminal kinase SOD, superoxide dismutase MMP (ΔΨm), mitochondrial membrane potential FBS, fetal bovine serum PI, propidium iodide FITC, fluorescein isothiocyanate H2DCFDA, 2&prime ,7&prime -dichlorodihydrofluorescein diacetate DHE, dihydroethidium GSH, glutathione CMFDA, 5-chloromethylfluorescein diacetate MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide |
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