Sleep quality in patients with xerostomia: a prospective and randomized case-control study

Objectives To investigate sleep quality, anxiety/depression and quality-of-life in patients with xerostomia. Materials and methods This prospective, observational, cross-sectional study was conducted among a group of xerostomia patients (n?=?30) compared with 30 matched control subjects. The following evaluation scales were used to assess the psychological profile of each patient: the Hospital Anxiety and Depression Scale, the Oral Health Impact Profile-14 (OHIP-14), the Xerostomia Inventory, the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). Results The PSQI obtained 5.3 3?±?1.78 for patients with xerostomia compared with 4.26?±?1.01 for control subjects (p?=?0.006); ESS obtained 5.7?±?2.1 for test patients vs 4.4 0?±?1 for control subjects (p?=?0.010). Statistical regression analysis showed that xerostomia was significantly associated with depression (p?=?0.027). Conclusions Patients with xerostomia exhibited significant decreases in sleep quality compared with control subjects.