自由基清除剂治疗实验性大鼠慢性细菌性前列腺炎的研究

目的: 探讨自由基清除剂在慢性细菌性前列腺炎 (CBP)中的治疗作用。　方法: ①将 58只健康雄性SD大鼠随机分为正常对照组(10只)与实验组(48只),后者通过利用微创技术开腹在直视下前列腺局部注射大肠埃希菌制备CBP动物模型;②将实验组动物随机分为A、B、C、D4组,A组不经任何药物处理,B、C、D组分别予维生素C、柳氮磺胺吡啶(SASP)、维生素C+SASP治疗;③检测前列腺组织超氧化物歧化酶(SOD)活力、丙二醛 (MDA)含量。　结果: 维生素C能明显提高SOD的水平和降低MDA的水平。实验组与对照组、治疗组与未治疗组差异有显著性(P>0. 05),但治疗组之间差异无显著性(P<0. 05)。　结论: 自由基清除剂可能成为治疗CBP的一种新方法。

Treatment of Experimental Chronic Bacterial Prostatitis with Free-radical Scavenger in Rats

Objective: To evaluate the efficacy of free-radical scavenger in the treatment of chronic bacterial prostatitis(CBP). Methods: Fifty-eight healthy male rats were randomly divided into a control group and four model groups(Groups A, B, C and D). The chronic prostatitis model was established in the latter groups through injecting E.coli into the ventral robe of the prostate according to document. Group A was untreated, Group B treated with free-radical scavenger vitamin C, Group C with salicylazosulfapyridine (SASP), Group D with SASP and vitamin C. Superoxide dismutase (SOD) and malondialdehyde (MDA) examinations were conducted in each group 2 months later. Results: Vitamin C could significantly increase the level of SOD and decrease the level of MDA. There was significant difference between the model groups and the control one, as well as between the treated groups and the untreated one, but none among the treated groups. Conclusion: Free-radical scavenger may be useful for the treatment of chronic bacterial prostatitis.