Mycosis fungoides and chronic lymphocytic leukaemia--composite T-cell and B-cell lymphomas presenting in the skin |
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Authors: | Hull P R Saxena A |
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Institution: | Division of Dermatology, Department of Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada S7N 0W8. hullp@attglobal.net |
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Abstract: | Composite lymphomas involving cutaneous B-cell and T-cell lymphomas are very uncommon. We report here the unique circumstance of a patient with mycosis fungoides (primary cutaneous T-cell lymphoma) who later developed chronic lymphocytic leukaemia (B-cell lymphoproliferation, B-CLL), which presented in the skin (leukaemia cutis) as a composite lymphoma affecting an earlobe. The presence of both lymphoproliferative disorders was confirmed with immunophenotyping and the finding of both immunoglobulin gene rearrangements and T-cell receptor gene rearrangements in the ear and the same T-cell receptor gene rearrangement in a plaque lesion of mycosis fungoides on the arm. |
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Keywords: | B-CLL chronic lymphocytic leukaemia composite lymphoma leukaemia cutis mycosis fungoides secondary lymphoma T-cell and B-cell lymphomas |
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