三维适形放射治疗颈段食管癌的疗效观察

目的探讨三维适形放射治疗颈段食管癌的疗效,分析影响其预后的因素。方法回顾性分析17例颈段食管癌患者接受三维适形放射治疗（1.8－2.0 Gy/次,5次/周,总剂量63－70 Gy,6－7周完成）的疗效,生存分析采用Kplan-Meier法,多因素分析采用Cox比例风险模型。结果三维适形放射治疗1、2年局部控制率为97.3%、91.7%;1、2年生存率分别为94.1%、86.2%;1、2年无瘤生存率分别为68.8%、62.2%。急性放射反应主要是急性放射性食管炎和急性放射性气管炎,多为1－2级。多因素分析结果显示T、N分期和病变长度是影响预后的主要因素。结论三维适形放射治疗是治疗颈段食管癌的有效方法。T、N分期和病变长度对患者的预后有重要影响。

Effecting Observation of 3-Dimensional Conformal Radiotherapy for Cervical Esophageal Cancer

Objective To evaluate the effects and analyze the prognosticators of 3 -dimensional conformal radiotherapy for eerviaal esophageal cancer. Methods 17 cir~ical and esophageal cancer patients were treated with 3 - dimensional conformal radiotherapy （ 1.8 -2.0 Gy per day,5 times a week,a total dose of 63 -70 Gy of 6 -7 weeks ）. Acute errects and survival tares were observed. Kaplan - Meier method was ysed for survival analysis, Cox proportional hazard model in multivariate analyses. Results The 1,2 years local control rate was 90.3% ,81.7% respectively. The 1,2 years disease -free survival and overall were 94.1%, 86.2%, and 68.8% , 62.2% respectively. Acute esophagitis and bronchitis were the most common but acceptable radioreaetions Grade 1 - 2. Multivariate analyses revealed that the T and N stage and tumor in length were independent factors of pronosis （ P 〈 0.05 ）. Conclusions 3 - Dimensional conformal radiotherapy can be considered as an effective and feasible approach to cervical and upperthoracic esophageal cancer patients. T and N stage and tumor in length were identified as cervical and upper - thoracic esophageal cancer predictors.