Evaluation of some classical hydrazones of ketones and 1,2-diketones as antileishmanial, antibacterial and antifungal agents |
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| Authors: | Yasser M. S. A. Al-kahraman Masoom Yasinzai Girija S. Singh |
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| Affiliation: | Institute of Biochemistry, University of Baluchistan, Quetta, Pakistan. |
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| Abstract: | The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4'-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed. |
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