History and rationale of genetic toxicity testing: an impersonal, and sometimes personal, view |
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| Authors: | Zeiger Errol |
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| Affiliation: | Errol Zeiger Consulting, Chapel Hill, North Carolina 27514, USA. zeiger@nc.rr.com |
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| Abstract: | Genetic toxicity testing is a necessary and pivotal component of product development and registration. This article traces the historical development and evolution of genetic toxicity testing, and the rationale for such testing, and identifies some of the individuals who played key roles in this process. The evolution of the present test batteries and some of the research and rationales behind the decisions to accept or reject tests are described. |
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| Keywords: | genetic toxicology genotoxicity testing mutagen assays test tiers and batteries history of science |
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