| 肾上腺肿瘤DNA含量测定的临床意义 |
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| 引用本文： | 毕新刚,马建辉,寿建忠,许秉责. 肾上腺肿瘤DNA含量测定的临床意义[J]. 中国现代医学杂志, 1998, 0(10) |
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| 作者姓名： | 毕新刚 马建辉 寿建忠 许秉责 |
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| 作者单位： | 中国医学科学院协和医科大学肿瘤医院泌尿外科!北京100021 |
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| 摘 要： | 为明确DNA含量可否作为肾上腺肿瘤良恶性诊断的指标 ,采用FCM技术对肾上腺嗜铬细胞瘤 10例以及肾上腺皮质肿瘤 7例新鲜标本进行了DNA含量的测定。6例病理为皮质腺瘤标本 ,2例DNA含量为非整倍体 ,其中 1例出现肝转移而确诊为恶性 ,1例皮质腺癌为二倍体的患者无瘤生存 ,而肾上腺嗜铬细胞瘤以及瘤旁肾上腺标本DNA含量均为非整倍体 ,但病理学及随访均不支持恶性。认为采用FCM技术测定肾上腺肿瘤DNA含量对判断皮质肿瘤良恶性可能是一项重要方法 ,但对嗜铬细胞瘤的作用不大
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| 关 键 词： | 肾上腺肿瘤 DNA倍体 |
NUCLEAR DNA CONTENT STUDIED BY FLOW CYTOMETRY IN ADRENAL TUMOR AND ITS CLINICAL SIGNIFICANCE |
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| Bi Xingang,Ma Jianhui,Shou Jianzhong. NUCLEAR DNA CONTENT STUDIED BY FLOW CYTOMETRY IN ADRENAL TUMOR AND ITS CLINICAL SIGNIFICANCE[J]. China Journal of Modern Medicine, 1998, 0(10) |
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| Authors: | Bi Xingang Ma Jianhui Shou Jianzhong |
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| Affiliation: | Bi Xingang,Ma Jianhui,Shou Jianzhong,Department of Urology,Cancer Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100021,P.R.China |
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| Abstract: | This study is designed to determine the diagnostic value of detecting nuclear DNA content by flow cytometry in adrenal tumor. DNA ploidy were investigated in fresh samples from 7 adrenocortical tumors and 10 pheochromocytomas. The results showed that all the pheochromocytomas and normal adrenal glands adjunct to pheochromocytomas were aneuploid, but there no evidence of malignancy in pathology and follow up. Among 6 adrnocortical adenomas, 2 cases were aneuploid, one of which died from liver metastasis, while 1 case carcinoma was diploid, who was alive without evidence of disease. In conclusion, the assessment of ploidy level by flow cytometry, may be very useful tool in the diagnosis adrenocortical neoplasms, but as for pheochromocytoma, it's less useful. |
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| Keywords: | Adrenal tumor DNA ploidy |
| 本文献已被 CNKI 等数据库收录！ |
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