1，6—二磷酸果糖和巯甲丙脯酸对心脏术后心肌缺血—再灌注损伤的保护

目的：探讨1，6－二磷酸果糖（FDP）和巯甲丙腈酸（CAP）增强心脏停搏液对缺血心肌保护的临床效果，方法：将60例患者随机分成三组，I组：作为对照组，应用我院体外循环下心肌保护方法，即首剂应用冷钾晶体心脏停搏液，从第二剂量开始改用15度稀释氧合血灌注，Ⅱ组：在冷钾晶体心脏停搏液中加入FDP（5mmol/L)；Ⅲ组：在冷钾晶体心脏停搏液中加FDP（5mmol/L)和CAP（12．5mg/L)。观察血浆丙二醛（MDA），肌酸磷酸激酶同工酶（CPK－MB），血栓素B2（TXB2），6－酮－前列腺素F1（6－酮－PGF1a)及电子显微镜检查结果：结果：与I组比较，Ⅱ组和Ⅲ组MDA，CPK－MB明显降低，且Ⅲ组较好地维持了TXB2和6－酮－PGF1a二者的比例平衡，Ⅱ组和Ⅲ组对线粒体也有较好地保护及提高毛细血管通畅率的作用。结论：FDP和CAP能明显增加心脏停搏液对缺血心肌保护的效果。

Protective Effects of Cardioplegic Solution Containing Fructose-

Objective　To study protective effects of cardioplegic solution containing fructose-1,6-diphosphate and captopril on ischemic myocardium.　Methods　Sixty patients were randomly divided into 3 groups. Group Ⅰ: Control group, the clinical myocardial preservation method under extracorporeal circulation in our institution was used, namely, the cardioplegic solution of initial dose was cold potassium crystal cardioplegic solution, then the cold diluted oxygerated blood was given in the beginning from second dose. Group Ⅱ: 5mmol/L fructose-1,6-diphosphate were added to the cold potassium crystal cardioplegic solution. Group Ⅲ: 5mmol/L fructose-1,6-diphosphate and 12.5mg/L captopril were added to the cold potassium cardioplegic solution. The levels of malondialdehyde, creatine phospokinase MB, thromboxane B and 6-keto-prostaglandin F1α in plasma were measured. Quantitative study of the myocardial ultrastructure were also undertaken.　Results　Creatine phospokinase MB and malondialdehyde remarkably lower in both group Ⅱ and group Ⅲ than that in group Ⅰ; the well proportion of thromboxane B and 6-keto-prostaglandin F1α was maintained too in group Ⅲ; the function of mitochondria were effectively protected and the patent rate of capillaries was significantly increased in group Ⅱ and group Ⅲ.　Conclusion　Fructose-1,6-diphosphate and captopril could significantly strengthen the protective effects of cardioplegic solution on ischemic myocardium.