| 红花黄素对大鼠心肌缺血-再灌注模型的作用及机制研究 |
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| 引用本文： | 郑为超,陈铎葆,李兵,张雷.红花黄素对大鼠心肌缺血-再灌注模型的作用及机制研究[J].中国药理学通报,2003,19(9):1032-1034. |
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| 作者姓名： | 郑为超 陈铎葆 李兵 张雷 |
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| 作者单位： | 安徽理工大学医学院,淮南,232001 |
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| 基金项目： | 安徽省重点科研项目资金资助课题,No 01041183 |
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| 摘 要： | 目的 研究红花黄素对心肌缺血 -再灌注大鼠的影响。方法 建立大鼠冠脉结扎致心肌缺血 -再灌注损伤模型 ,观察红花黄素预防性给药对缺血大鼠血浆中肌酸磷酸激酶 (CPK)、乳酸脱氢酶 (LDH)活性及心肌和血浆中脂质过氧化物丙二醛 (MDA)含量 ,超氧化物歧化酶 (SOD)活性的影响。结果 红花黄素预防性给药能明显降低血浆CPK、LDH的活性及MDA含量 ,提高SOD的活性 ,具有明显的抗氧化性。结论 红花黄素对实验性心肌缺血 -再灌注大鼠具有明显的保护作用 ,其作用可能与其抗氧化有关
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| 关 键 词： | 红花黄素 缺血-再灌注 脂质过氧化 |
| 文章编号： | 1001-1978(2003)09-1032-03 |
| 修稿时间： | 2003年1月8日 |
The preventive effects of safflor yellow on myocardium injury of mycardium ischemic reperfusion in rats |
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| ZHENG Wei Chao,CHEN Duo Bao,LI Bing,ZHANG Lei.The preventive effects of safflor yellow on myocardium injury of mycardium ischemic reperfusion in rats[J].Chinese Pharmacological Bulletin,2003,19(9):1032-1034. |
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| Authors: | ZHENG Wei Chao CHEN Duo Bao LI Bing ZHANG Lei |
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| Abstract: | AIM The preventive effects of safflor yefflor (SY) on myocardium injury of myocardium ischemic reperfusion (I/R) was studied. METHODS The contents of MDA activity of SOD,as well as the activity of creatine phospho kinase(CK) and lactate dehydrogenase(LDH) were determined in rat models injured by I/R. RESULTS SY could reduce the activities of CK and LDH ,decrease the the content of MDA in plasmo, and increase the activities of SOD. CONCLUSION SY may obviously prevent the rat I/R model which may be related to its anti lipoperoxidation. |
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| Keywords: | safflor yellow ischemia reperfusion anti lipoperoxidation |
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