|
|||||
|
|
Expression of beta-catenin and APC protein in ovarian epithelial tumor and its implication |
|
| Authors: | Lin?Xiao,Li?Yu? author-information" > author-information__contact u-icon-before icon--email-before" > mailto:Liyu @.com" title=" Liyu @.com" itemprop=" email" class=" gtm-email-author" >Email author,Mi?Can |
| Affiliation: | (1) Department of Pathology, Chongqing University of Medical Science, Chongqing, 400016, China |
| Abstract: | Objective: To investigate the expression of beta-catenin, APC protein and its implication in ovarian epithelial tumor. Methods: Immunohistochemical staining with SP method was conducted to determine the expression of beta-catenin and APC protein in 48 cases of ovarian epithelial tumor. Results: The abnormal expression rates of beta-catenin in ovarian malignant and borderline epithelial tumors were higher than that in benign epithelial tumors. The expression of APC protein in benign epithelial tumors was significantly greater than that in malignant epithelial tumors. A significant negative correlation was found between beta-catenin and APC protein in ovarian epithelial tumors. Conclusion: Beta-catenin and APC protein have important effect on pathogenesis and development of ovarian epithelial tumors. |
| Keywords: | Beta-catenin APC protein Ovarian epithelial tumors |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ | |