534例高原急进人群肾上腺皮质机能观察

目的：探讨肾上腺皮质激素与急性高原病的关系。方法：分别在低海拔区和高海拔区及高海拔区不同时间抽取同一人群的肘静脉血检测血浆皮质醇（F）、醛固酮（札D）、肾素活性（PRA）、血管紧张素Ⅱ（AⅡ）及睾酮（T）等五项肾上腺皮质激素，进行统计学处理。通过分析找出与急性高原病的相关关系。结果：血浆皮质醇含量随海拔高度的增加而有增高，而ALD、PRA、AⅡ及T无统计学意义；进入高海拔区后，随着时间延长，血浆皮质醇含量明显下降。进入高海拔区后发病组人群血浆皮质醇含量明显低于未发病人群。结论：血浆皮质醇水平与急性高原病的发病明显相关。

OBSERVATION ON 534 CASES OF ADRENOCORTICAL FUNCTION IN RAPID ENTRY POPULATION TO PLATEAU

Objective： To investigate the relationship between the adrnocortical hormone level and acute mountain sickness. Methods：The blood sample was drawn from each object before,and after rapid entry to plateau（〉4700M above level）,and 15 doys and 60 days after they had been in the plateau above the same sea level;the plasma eortisol（F）,aldosterone（ALD）,renin（PRA）, angiotensin Ⅱ （AT Ⅱ ） and testosterone（T） levels were determined by RIA. Results ：The plasma F level increased signifcantly along with the increasing altitude, while the plasma ALD,PRA,AT Ⅱ and T value also increased, but without statistical significance; The results of rapid entry population to plateau in different intervals after entry to the same altitude showed that the plasma F level reduced significantly,the other 4 parameters changed slightly without statistical significance; After entry to high altitude regions, the plasma F level of persons with acute mountain sickness was significantly lower than that of the persons without onset of the sickness.Conclusion ：The correlation beween the plasma cortisol level and onset of acute mountain sickness is significant.