Distribution of components of 3 H-noradrenaline uptake in the wall of the rabbit aorta |
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| Authors: | J A Bevan R D Bevan J V Osher C Su |
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| Affiliation: | 1. Graduate School of Science and Engineering, Ehime University, 3 Bunkyo, Matsuyama, Ehime, Japan;2. Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, Japan;1. Far East Geological Institute, Far East Branch of Russian Academy of Sciences, 159 Prospect 100 let Vladivostoku, Vladivostok 690022, Russia;2. School of Earth Sciences and Resources, China University of Geosciences Beijing, 29 Xueyuan Road, Beijing 100083, China;3. School of Engineering, Far Eastern Federal University, 8 Suhanova St., Vladivostok 690950, Russia |
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| Abstract: | An analysis of the distribution of tritiated noradrenaline (3H-NA) in the wall of the rabbit thoracic aorta has been studied by a frozen-section technique.Some of the components of this uptake were defined by relating tritium distribution to histological structure and by determining the effect of tissue washing, electrical stimulation of the intramural nerves and pretreatment with phenoxybenzamine (PBZ) in a concentration that inhibits maximally 3H-NA binding.5 components of 3H-NA distribution in the vessel wall were defined; that (i) in the extracellular space, (ii) loosely bound to all tissues, (iii) specifically bound to sympathetic nerves, (iv) bound to non-nervous tissues at sites sensitive to PBZ, (v) bound to all tissues at sites insensitive to PBZ. |
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