Phase II Study of Ifosfamide+Doxorubicin in Patients With Advanced Synovial Sarcomas (E1793): A Trial of the Eastern Cooperative Oncology Group |
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| Authors: | Edmonson John H Ryan Louise M Falkson Carla I Hicks David G Blum Ronald H |
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| Affiliation: | M.D. Mayo Clinic 200 First Street SW Rochester MN 55905 USA. |
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| Abstract: | Purpose Because we had observed in the synovial sarcoma subgroup of a broad phase III advanced soft tissue sarcoma study asignificantly greater objective regression rate from ifosfamide+doxorubicin (88%) than from doxorubicin alone (20%)(P = 0.02), the Eastern Cooperative Oncology Group (ECOG) decided to further assess this two drug combination in a subsequent Phase II study. |
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