| Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activationOA |
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| 引用本文： | Zhen-ji Wang,Zhe Bai,Jing-hua Yan,Teng-teng Liu,Ying-mei Li,Jia-hui Xu,Xiao-qian Meng,Yue-feng Bi. Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activationOA[J]. 中草药(英文版), 2022, 14(1): 97-103. DOI: 10.1016/j.chmed.2021.11.002 |
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| 作者姓名： | Zhen-ji Wang Zhe Bai Jing-hua Yan Teng-teng Liu Ying-mei Li Jia-hui Xu Xiao-qian Meng Yue-feng Bi |
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| 作者单位： | aSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinabCollaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China;aSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450002, China;aSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450003, China;aSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450004, China;aSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450005, China;aSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450006, China |
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| 基金项目： | supported by the National Natural Science Foundation of China (grant numbers 81273392)；;the Natural Science Foundation of Henan Province (grant numbers 182300410348)； |
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| 摘 要： | Objective:The purpose of this study is to investigate the anti-diabetic effects of linarin,a flavonoid extracted from Chrysanthemi Indici Flos(CIF),and its potential mechanisms.Methods:The effects of linarin on cell viability and glucose consumption in Hep G2 cells were measured.Meanwhile,monosodium glutamate(MSG) mouse model was constructed to monitor the changes of insulin tolerance,glucose tolerance,triglyceride and cholesterol.The protein expression levels of pAMPK,p-ACC,PEPCK and p-GS were ...
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| 收稿时间： | 2021-01-31 |
Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation |
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| Zhen-ji Wang,Zhe Bai,Jing-hua Yan,Teng-teng Liu,Ying-mei Li,Jia-hui Xu,Xiao-qian Meng,Yue-feng Bi. Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation[J]. Chinese Herbal Medicines, 2022, 14(1): 97-103. DOI: 10.1016/j.chmed.2021.11.002 |
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| Authors: | Zhen-ji Wang Zhe Bai Jing-hua Yan Teng-teng Liu Ying-mei Li Jia-hui Xu Xiao-qian Meng Yue-feng Bi |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China;2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China |
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| Abstract: | Objective: The purpose of this study is to investigate the anti-diabetic effects of linarin, a flavonoid extracted from Chrysanthemi Indici Flos (CIF), and its potential mechanisms. Methods: The effects of linarin on cell viability and glucose consumption in HepG2 cells were measured. Meanwhile, monosodium glutamate (MSG) mouse model was constructed to monitor the changes of insulin tolerance, glucose tolerance, triglyceride and cholesterol. The protein expression levels of p-AMPK, p-ACC, PEPCK and p-GS were detected by Western blot.Results: Linarin could increase the relative glucose consumption of HepG2 cells, improve insulin tolerance and glucose tolerance, and decrease the levels of triglyceride and cholesterol of MSG mice. Simultaneously, the expression levels of p-AMPK and p-ACC in HepG2 cells and the liver tissue of MSG mice were increased, while the expression levels of PEPCK and p-GS were decreased after treatment with linarin.Conclusion: Insulin resistance could be ameliorated by linarin in type 2 diabetes, and its mechanism may be related to AMPK signaling pathway. |
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| Keywords: | AMPK anti-diabetes Chrysanthemi Indici Flos insulin resistance linarin type 2 diabetes |
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