| 高危型HPV在泌尿生殖系统肿瘤研究中的进展 |
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| 引用本文： | 李红岩,侯振江.高危型HPV在泌尿生殖系统肿瘤研究中的进展[J].医学综述,2012,18(10):1481-1483. |
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| 作者姓名： | 李红岩 侯振江 |
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| 作者单位： | 沧州医学高等专科学校医学技术系检验教研室 |
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| 摘 要： | 人乳头瘤病毒(HPV)是一种嗜鳞状上皮细胞的病毒,高危型HPV的基因产物E6、E7具有细胞转化功能;E6通过使p53蛋白大量表达,并与野生型p53结合,使后者丧失修复损伤DNA的功能,导致肿瘤的发生。通过研究高危型HPV与宫颈癌、膀胱癌、阴茎癌、子宫内膜癌等泌尿生殖系统肿瘤的相关性,可以为肿瘤的诊断、治疗、预测提供理论依据。
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| 关 键 词： | 人乳头瘤病毒 肿瘤 泌尿生殖系统 |
Research Progress on the Relation of High-risk Human Papillomavirus and Neoplasm of Genitourinary System |
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| LI Hong-yan,HOU Zhen-jiang.Research Progress on the Relation of High-risk Human Papillomavirus and Neoplasm of Genitourinary System[J].Medical Recapitulate,2012,18(10):1481-1483. |
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| Authors: | LI Hong-yan HOU Zhen-jiang |
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| Institution: | .(Staff Room of Laboratory,Department of Medical Technology,Cangzhou Medical College,Cangzhou 061000,China) |
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| Abstract: | Human papillomavirus(HPV)is a kind of squamous epithelial cells tropic virus.High-risk HPV gene products E6 and E7 have cell transformation function.E6 through causing p53 protein abundant expression and combination with the wild type p53 to make the latter lose function of repairing the damaged DNA,which results in tumors.It can provide the theory basis for the diagnosis,treatment and predict of cancer by researching the correlation between the high-risk HPV and neoplasms of genito-urinary system such as cervical cancer,bladder cancer,penile cancer and endometrial cancer. |
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| Keywords: | Human papilloma virus Neoplasm Genitourinary System |
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