老年人胃黄色瘤与幽门螺杆菌感染的相关性分析

目的 了解老年慢性胃炎患者黄色瘤与幽门螺杆菌(Hp)感染之间的相关关系.方法 对2010年1月至2011年12月在该院接受胃镜检查的60岁以上的慢性胃炎患者499例根据病理结果分为黄色瘤组186例和非黄色瘤组313例,分别观察两组患者胃黏膜Hp感染、中性粒细胞浸润、腺体萎缩、淋巴滤泡等病理表现.结果 黄色瘤组与非黄色瘤组比较,Hp感染率(52.7％、37.3％)、中性粒细胞浸润率(35.5％、24.0％)、腺体萎缩率(36.6％、3.5％)均明显升高(x210.677、7.641、95.606,P＜0.01)；两组淋巴滤泡检出率(21.0％、20.8％)比较,差异无统计学意义(x2=0.003,P=0.957).Hp 感染者中性粒细胞浸润(45.8％)、淋巴滤泡检出率(42.6％)均高于Hp阴性者(14.8％、4.2％),差异均有统计学意义(P=0.000).结论 胃黄色瘤与Hp感染、中性粒细胞浸润、腺体萎缩相关,淋巴滤泡形成与Hp感染密切相关,应加强对老年慢性胃炎患者Hp的根治.

Relationship between gastric xanthelasma and Helicobacter pylori infection in elderly

Objective To understand the relationship between xanthelasma in elderly patients with chronic gastritis and Helicobacter pylori(Hp) infection.Methods From January 2010 to December 2011,499 cases of chronic gastritis aged over 60 years in our hospital received gastroscopy and were divided into the xanthelasma group(186 cases)and the non-xanthelasma group(313 cases) according to the pathological findings.Hp infection,neutrophil infiltration,glandular atrophy,lymphoid follicles and other pathological manifestations in gastric mucosa were observed in each group.Results Comparing the xanthelasma group with the non-xanthelasma group,Hp infection rate(52.7% vs.37.3%),neutrophil infiltration rate(35.5% vs.24.0%),glandular atrophy(36.6% vs.3.5%)were significantly increased(χ2=10.677,7.641,95.606,P<0.01);the detection rate of lymph follicles(21.0% vs.20.8%) had no statistical difference(χ2=0.003,P=0.957).In Hp infection patients,neutrophil infiltration(45.8%) and lymphoid follicles detection rate(42.6%) were higher than those in the Hp-negative group(14.8%,4.2%),differences were statistically significant(P=0.000).Conclusion Gastric mucosal xanthelasma is associated with Hp infection,neutrophil infiltration and glandular atrophy and lymphoid follicle formation is closely related to Hp infection.Ratical treatment of Hp in elderly patients with chronic gastritis should be strengthened.