肿瘤分子分型研究及其对检验医学的启迪

肿瘤分子分型是从系统生物学角度,采用现代新型高通量分子分析技术,在DNA、RNA或蛋白质水平根据分子遗传学或分子生物学改变特征对肿瘤进行分类分型.分子分型可对组织形态学诊断进行积极的补充.肿瘤分子分型与个体化诊治关系密切,体现了目前肿瘤基础和临床研究的最新成果,具有重要的临床意义.分子分型的最终目标是明确个体肿瘤的分子特征,针对该特征选择最适当的治疗方案或靶向药物,真正使患者最大程度获益.

Current trends in molecular classification of cancers

Tumor morphology from the microscopic appearance has being served as the basis of tumor classification,but has serious 1imitations.Molecular aberrations,including DNA,RNA and protein,ale playing an ever increasing role in guiding classification,prognosis,and therapeutic strategies in cancer patients.A specific molecular profile correlating with important clinical parameters should allow physicians to base management decisions on the molecular characteristics of an individual patient's tumor.The application of high-throughput technologies to tumor,3 should make it possible to generate comprehensive molecular profiles.The integration of clinical,morphological and molecular data could result in a more precise classification of cancers,and lead to better understanding,individualized predicting and treatment,which would give the maximum benefit to the patients.