| 二乙基二硫代氨基甲酸钠对沙土鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 李飒,李万亥,陶学斌,陈东明,陈洁.二乙基二硫代氨基甲酸钠对沙土鼠脑缺血再灌注损伤的保护作用[J].药学实践杂志,1995,13(3):136-139. |
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| 作者姓名： | 李飒 李万亥 陶学斌 陈东明 陈洁 |
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| 作者单位： | 第二军医大学药学院中西药研究室，广州市第一军医大学南方科研药厂 |
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| 摘 要： | 蒙古沙土鼠脑缺血６０ｍｉｎ后，脑组织能量物质ＡＴＰ、ＡＤＰ明显下降，且有可检测的次黄嘌呤产生；氧在含量上有趋势。再灌注５ｍｉｎ，氧自由基含量显著增加；灌注３０ｍｉｎ时，ＡＴＰ、ＡＤＰ有所回，ＨＸ降至无法检测ＯＦＲ降于缺血组水平。
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| 关 键 词： | 二乙基 二硫代氨基甲酸 脑缺血 再灌注损伤 |
Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil |
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| Li S,Li Wanhai,Tao Xuebin,Chen Dongming and Chen Jie.Protective effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil[J].The Journal of Pharmaceutical Practice,1995,13(3):136-139. |
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| Authors: | Li S Li Wanhai Tao Xuebin Chen Dongming and Chen Jie |
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| Institution: | Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433;Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433;Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433;Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433;Department of Natural and Synthetic Drug Research, College of Pharmacy, Second Militray Medical University Shanghai 200433 |
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| Abstract: | Brain injury in Mongolian gerbil(Meriones unguiculatus) was induced by occluding bilateral common carotid arteries followed by reperfusion. Levels of ATP, ADP and HX in gerbil brain measured by HPLC method were decreased and increased significantly respectively after 60 min cerebral ischemia. The level of oxygen free radicals(OFR) measured by electron spin resonance(ESR)were increased significantly only at 5-min reperfusion. DTC, iv 50 mg·kg-115 min before occlusion, increased level of ATP and ADP in brain,reduced edema of neuron and tissue of brain and decreased the level of OFR in 5-min reperfusion group and the mortality of gerbil to 50% as dexame thasone did in the reperfusion group. The results suggested that DTC had protective effects on ischemia-reperfusion induced gerbil brain injury. The OFR in gerbil brain may be formated mainly by the route of xanthine oxidase. |
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| Keywords: | diethyldithiocarbamate adenosine triphosphate oxygen free radicals Mongolian gerbil ischemia-reperfusion-induced brain injury |
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