| 核因子-κB在正常妊娠和妊娠期肝内胆汁淤积症胎盘中表达的意义 |
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| 引用本文： | 刘志杰. 核因子-κB在正常妊娠和妊娠期肝内胆汁淤积症胎盘中表达的意义[J]. 西北国防医学杂志, 2008, 29(6) |
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| 作者姓名： | 刘志杰 |
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| 作者单位： | 兰州军区兰州总医院妇产科,甘肃,兰州,730050 |
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| 摘 要： | 目的:探讨正常和妊娠期肝内胆汁淤积症(ICP)胎盘组织中核因子-κB(NF-κB)表达的意义。方法:采用组织微阵列技术和免疫组织化学染色方法检测正常胎盘(30例)和ICP胎盘(轻度28例,重度19例)组织中NF-κB p65蛋白的表达水平。结果:NF-κB p65在正常胎盘和ICP胎盘绒毛表面合体滋养细胞胞浆和胞核内呈阳性表达,绒毛间质的血管平滑肌和内皮细胞内表达较少;ICP重度组单位胎盘面积IOD最高(95.69±13.49),ICP轻度组次之(71.37±7.74),正常胎盘最低(57.54±4.13),三组间差异显著(P<0.01)。结论:ICP胎盘组织NF-κB表达明显增高,且与ICP的疾病程度有关,NF-κB激活与ICP发生发展过程有关。
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| 关 键 词： | 妊娠期肝内胆汁淤积症 胎盘 核因子-κB |
Expression of nuclear factor-κB in placenta of normal pregnancy and intrahepatic cholestasis of pregnancy and its significance |
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| LIU Zhi-jie. Expression of nuclear factor-κB in placenta of normal pregnancy and intrahepatic cholestasis of pregnancy and its significance[J]. Medical Journal of National Defending Forces in Northwest China, 2008, 29(6) |
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| Authors: | LIU Zhi-jie |
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| Affiliation: | LIU Zhi-jie.(Department of Obstetrics and Gynecology; Lanzhou General Hospital; Lanzhou Command; PLA; Lanzhou 730050; China); |
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| Abstract: | Objective:To explore the expression of nuclear factor kappa B(NF-κB) in placenta of normal pregnancy and intrahepatic cholestasis of pregnancy(ICP) and to analyze the clinical significance.Methods: Forty-seven ICP patients were graded into mild ICP group(n=28,TBA<40 μmol/L) and severe ICP group(n=19,TBA≥40 μmol/L) based on serum total bile acid(TBA) level.The expression of NF-κB p65 protein in normal(n=30,control group) and ICP placenta was determined by immunohistochemistry combined with tissue microarr... |
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| Keywords: | Intrahepatic cholestasis of pregnancy Placenta Nuclear factor kappa B |
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