莫西沙星致肝肾功能异常

1例83岁男性患者,因肺炎给予莫西沙星0.4g加入0.9%氯化钠注射液,1次/d静脉滴注;异丙托溴铵和沙丁胺醇雾化吸入。第2天血生化检查：ALT201U/L,AST455U/L,TBil60μmol/L,皮肤及巩膜轻度黄染。之后,黄染进行性加深。实验室检查：TBil126μmol/L,DBil98.6μmol/L;CCr187.5μmol/L,BUN40.16mmol/L;24h尿蛋白定量测定0.8g。停用莫西沙星,改为头孢曲松与阿奇霉素联合使用。23d后其血生化检查基本恢复正常,黄疸消退。

Abnormal liver and renal function due to moxifloxacin

A 83-year-old man with pneumonia received an IV infusion of moxifloxacin 0.4 g in 0.9% sodium chloride once daily and aerosol inhalation of ipratropium bromide and salbutamol. On day 2,biochemical tests showed an ALT level of 201 U/L,an AST level of 455 U/L,and a TBil level of 60 μmol/L. Meanwhile he experienced yellowish skin and sclera. Subsequently,his jaundice progressively worsened and laboratory examinations revealed the following values：TBil 126 μmol/L,DBil 98.6 μmol/L,CCr 187.5 μmol/L,BUN 40.16 mmol/L,24-hour urine protein 0.8 g. Moxifloxacin was withdrawn and changed to concomitant use of cefatriaxone and azithromycin. Twenty-three days later,the patient＇s biochemical tests basically returned to normal.