多种肿瘤标志物联合检测在常见恶性肿瘤诊治中的价值

目的探讨甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原153(CA153)、糖类抗原125(CA125)及铁蛋白(FER)在恶性肿瘤诊断及疗效判断中的应用价值。方法用罗氏E411全自动电化学发光仪对健康对照组、良性疾病组和恶性肿瘤患者血清中6种肿瘤标志物进行系统检测。结果肿瘤标志物在恶性肿瘤患者中的表达明显高于良性疾病组和健康对照组,肿瘤标志物联合检测的阳性率(55.0%～98.2%)高于单项检测(乳腺癌除外),差异有统计学意义(P<0.01)。结论多肿瘤标志物的联合检测对临床恶性肿瘤的辅助诊断、治疗、转移、复发和预后具有重要价值。

Diagnostic and therapeutic value of combined detection of multi-tumor markers in common malignant tumor

Objective To explore the application value of AFP,CEA,CA199,CA125, CA153 and FER tumor markers in combination for the diagnosis of malignant tumor. Methods The serum levels of six tumor markers AFP, CEA,CA199,CA125,CA153 and FER were detected by E411 electrochemiluminescence analyzer in healthy adults, the patients with benign disease and the patients with malignant tumor. Results The~serum levels of six tumor mark- ers were significantly higher in the patients with malignant tumor than in benign disease patients and healthy adults, the positive rates of combined detection（55.0%--98.20%） were higher than tumor markers used only with the exception of breast cancer. The difference was statistically significant（P〈0.01）. Conclusion Multiple combined detection of tumor markers for tumor diagnosis, therapy, metastasis, recurrence and prognosis has important value.