慢性乙型肝炎的血清血小板衍生生长因子BB检测相关性分析

目的通过对慢性乙型肝炎（CHB）患者血清血小板衍生生长因子BB（PDGF-BB）与血清HBV DNA水平、肝功能损害程度和肝纤维化的相关性分析,以探讨血清PDGF-BB水平在CHB中的应用价值。方法对CHB血清PDGF-BB水平与血清HBV DNA水平、肝功能、血清肝纤维化指标进行相关性分析;并将CHB分为轻度、中度、重度3组,分析血清PDGF-BB水平与血清HBV DNA水平、肝功能分级和肝纤维化指标的相关性。结果 CHB患者血清PDGF-BB水平与肝功能、血清肝纤维化指标均显著相关（P〈0.01）;与肝功能分级和血清肝纤维化指标均呈正相关（P〈0.05）;与血清HBV DNA水平无相关性,差异无统计学意义（P〉0.05）。结论血清PDGF-BB水平与CHB病情发展密切相关,不但可反映CHB患者的肝功能损害程度,也可反映CHB肝纤维化程度,可应用于CHB的肝功能和肝纤维化程度的评估。

The diagnostic correlation analysis of platelet derived growth factor BB in chronic hepatitis B

Objective Analyzing the applying value of serum level of platelet derived growth factor BB（PDGF-BB） in chronic hepatitis B（CHB） to study the diagnostic correlation of PDGF-BB level,HBV DNA level,liver function damage,liver fibrosis in CHB patients.Methods The PDGF-BB level,HBV DNA level,liver function and serum hepatic fibrosis indices were detected.The CHB patients were divided into the mild,moderate,and severe groups for correlation analysis of the serum PDGF-BB level with HBV DNA level,liver function damage and liver fibrosis.Results The PDGF-BB level had linear correlation with liver function and liver fibrosis indices（P0.01）,it was also positively correlated with the liver function classification and liver fibrosis indices（P0.05）,and it was not significantly correlated with the HBV DNA level（P0.05）.Conclusion The serum level of PDGF-BB is closely related to the development of CHB disease.It can show not only about degree of liver damage,but also about liver fibrosis degree.PDGF-BB level can be a serum index in evaluating degrees of liver damage and liver fibrosis.