CEA、CA199联合检测在结直肠癌的表达及临床意义

目的讨论癌胚抗原(CEA)、糖类抗原199(CA199)在结直肠患者血清中的表达及临床意义。方法通过化学发光免疫法对该院收治的112例结直肠癌患者在手术前、手术后3个月血清CEA、CA199进行检测,分析检测结果与直结肠癌诊断及预后的关系。结果手术前直结肠癌患者血清内CEA、CA199水平明显高于对照组(P<0.05),术后经3个月化疗后患者CEA、CA199水平与对照组差异无统计学意义(P>0.05)。结论通过检测结直肠癌患者血清CEA、CA199的表达可辅助临床诊断和对预后进行推测,检测提高了结直肠癌患者诊断阳性率同时可对化疗效果进行评定。

The expression and clinical significance of combined detection of CEA and CA199 in colorectal carcinoma

Objective To study the preoperative and postoperative expressions and the clinical significance of carcinoembryonic antigen（CEA） ,carbohydrate antigen （CA199） in colorectal carcinoma. Methods The preoperative and 3 months postoperative changes of CEA and CA199 of 70 cases Of patients with colorectal carcinoma were evaluated by chemiluminescence immunoassay,and the relationship between the diagnosis and postoperative chemotherapy clinical characteristics of colorectal carcinoma was analyzed. Results T.he values of CEA and CA199 in patients with colorectal carcinoma in preoperation were higher than the patients underwent postoperative chemotherapy and the healthy individuals （P〈0.05）. After received chemotherapy for 3 months,the levels of CEA and CA199 of patients with colorectal carcinoma showed no difference compared with the healthy individuals （P〉0.05）. Conclusion Combined detection of CEA and CA199 can be used in diagnosing and evaluating the prognosis of colorectal carcinoma.