子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达 |
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引用本文: | 令狐华,徐小蓉,庄琳,周晓,赵建武. 子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达[J]. 重庆医科大学学报, 2002, 27(4): 383-385 |
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作者姓名: | 令狐华 徐小蓉 庄琳 周晓 赵建武 |
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作者单位: | 1. 重庆医科大学临床学院妇产科,重庆,400016 2. 四川省妇幼保健院,成都,610041 3. 重庆市第四人民医院,重庆,400014 4. 重庆医科大学第二临床学院,重庆,400010 |
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摘 要: | 目的:检测子宫内膜异位症(EM)患者在位及异位内膜中Fas,FasL蛋白的表达, 探讨其在子宫内膜异位症免疫发病机制中的作用。方法:采用免疫组织化学(SP)法分别测定了EM患者在位和异位内膜及正常对照子宫内膜中Fas,FasL蛋白的表达。 结果:1、EM患者在位内膜及正常对照子宫内膜中Fas及FasL的表达均呈周期性改变,增生期呈低水平表达,分泌期表达增高, 两组间同期别比较增生期无显著差异,分泌期EM患者在位内膜的Fas及FasL表达均低于正常对照组;2、异位子宫内膜中的Fas及FasL的表达都呈现低水平或不表达。结论:子宫内膜异位种植可能与Fas及FasL的表达障碍有关。
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关 键 词: | 子宫内膜异位 子宫内膜 Fas Fas Liand |
文章编号: | 0253-3626(2002)04-0383-03 |
修稿时间: | 2001-03-12 |
Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis |
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Abstract: | Objective: To investigate the effect of Fas/ Fas ligand expression on the pathogenesis of endometriosis( EM ). Methods: Immunohistochemistry was used to assess the expression of Fas and Fas ligand (FasL) in ectopic and eutopic endometrium from patients with EM and those from controls. Results: Eutopic endometrium showed a cyclic change in correlation with the menstrual cycle both in patients with EM and in controls, with Fas/FasL staining found to be increased in secretory phase compared with those in proliferative phase. Although no difference was found between patients with EM and control in their Fas/FasL expression in proliferative phase, there was a decreased level of Fas/ FasL expression in secretory endometria of patients with EM . Notably, expression of the two parameters in ectopic endometrium was observed to be quite low. Conclusion:The low level of Fas and FasL expression in secretory eutopic endometrium and in ectopic endometrium may participate in the ectopic transplantation of endometriosis. |
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Keywords: | Endometriosis Endometrium Fas Fas ligand |
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