妊娠期肝内胆汁瘀积症血清胆汁酸值与胎儿窘迫的相关性分析

目的 探讨妊娠期肝内胆汁瘀积症患者的血清胆汁酸与胎儿窘迫的关系.方法 回顾性分析昆明医科大学附属甘美医院2007年1月至2013年10月收治的120例妊娠期肝内胆汁瘀积症患者的临床资料,并依据血清胆汁酸值将患者分成轻度与重度两组,统计患者的分娩方式,胎儿窘迫发生率等资料.结果 2组患者的年龄差异无统计学意义（P＞0.05）,重度患者的剖腹产率（28.46％）及胎儿窘迫发生率明显高于轻度患者（35.88％）.结论 妊娠期肝内胆汁瘀积症患者在妊娠末期需要严密监测血清胆汁酸值,对于高危患者要把握终止妊娠时机,切实保护母婴健康.

Correlation Analysis of Serum Bile Acid and Fetal Distress in Patients with Intrahepatic Cholestasis of Pregnancy

Objective To investigate the relationship between serum bile acid and fetal distress in patients with intrahepatic cholestasis of pregnancy.Methods The clinical data of 120 patients with intrahepatic cholestasis of pregnancy were retrospectively analyzed during January 2007 to October 2013.Patients were divided into mild and severe groups according to serum bile acid value.The information of delivery mode and the incidence of fetal distress were collected.Results There was no statistically significant difference in age of patients between the two groups.The caesarean section rate and incidence of fatal distress in severe group was significantly higher than those of mild patients.Conclusion In the late pregnancy of patients with intrahepatic cholestasis of pregnancy requires close monitoring of serum bile acid value.High-risk patients should be prepared to grasp the opportunity to terminate the pregnancy to ensure maternal and child health.