| 阿尔采默氏病危险因素的病例对照研究 |
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| 引用本文： | 沈渔邨,李永彤,李格,陈昌惠,李淑然. 阿尔采默氏病危险因素的病例对照研究[J]. 北京大学学报(医学版), 1992, 0(4) |
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| 作者姓名： | 沈渔邨 李永彤 李格 陈昌惠 李淑然 |
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| 作者单位： | 北京医科大学精神卫生研究所(沈渔邨，李永彤，李格，陈昌惠)，北京医科大学精神卫生研究所(李淑然) |
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| 摘 要： | 对阿尔采默氏病(Alzheimer Disease,AD)的可能危险因素进行了病例对照研究。126例临床确诊为 AD的病例,实施1:2匹配,以年龄、性别、民族、居住区为匹配条件的252名非痴呆者作为对照。发现与AD发生有明显关联的因素有:一级亲属痴呆家族史,一级亲属重性精神病家族史;病前兴趣狭窄以及一生中经历的重大生活事件。未发现Down氏症家族史及脑外伤史或过敏性疾病等与AD发生有明显关联。
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| 关 键 词： | 阿尔采默氏病 危险因素 Logistic回归 |
A CASE CONTROL STUDY OF RISK FACTORS ON ALZHEIMER''''S DISEASE |
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| Shen Yucun,et al Institute of Mental Health. A CASE CONTROL STUDY OF RISK FACTORS ON ALZHEIMER''''S DISEASE[J]. Journal of Peking University. Health sciences, 1992, 0(4) |
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| Authors: | Shen Yucun et al Institute of Mental Health |
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| Abstract: | A case control study to assess the possible risk factors associated with Alzheimer's discase (AD)among Chinese population was conducted on 126 clinically diagnosed AD patients and 252 matchedby sex, age, nationality region as control. Factors significantly associated with AD caseswere, family history of dementia in first degree relatives, family history of psychoses in first degreerelatives, few interesls and heavy negative life events during individuat's life time Neither famity his-tory of Down's syndrome, antecedent history of head trauma, nor other condition that might supportimmune hypotheses were significantly associated with AD cases The data from this study support thefamily genetic hypothese of AD and also the role of psychosocl factors in AD. |
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| Keywords: | Alzheimer's disease Risk factors Case control study |
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