辛伐他汀对2型糖尿病肾病患者血浆神经肽Y的影响

目的研究辛伐他汀对2型糖尿病肾病患者血浆神经肽Y（NPY）的影响。方法将160例2型糖尿病肾病患者随机分为对照组和试验组；对照组给予基础降糖药或胰岛素治疗，试验组在基础降糖药或胰岛素治疗的基础上给予辛伐他汀治疗，观察比较两组的治疗效果及治疗前后血浆NPY水平变化。结果试验组患者的总有效率（78．25％）明显高于对照组（61．25％），P〈0．05；两组患者治疗后尿白蛋白和血浆NPY含量均显著降低（P〈0．05），且试验组明显优于对照组（P〈0．05）。结论辛伐他汀具有明显降低血浆NPY含量的作用，能改善2型糖尿病肾病患者的尿蛋白，有助于延缓肾病进展。

Effects of simvastatin on plasma NPY in patients with type 2 diabetic nephropathy

Abstract： Objective To investigate the effects of simvastatin on plasma NPY in patients with diabetic nephropathy. Meth- ods A total of 160 cases with diabetic nephropathy were randomly divided into control group and experimental group. The subjects in control group received basic treatment of hypoglycemic drug or insulin. The subjects in experimental group received basic treat- ment as control group and combined with simvastatin. The levels of NPY were measured before and after treatment. The therapeu- tic effects of two groups were observed too. Results The total effective rate in the experimental group （78.25%）was significantly higher than that in the control group （61.25%）,P〈0.05. After treatment, the levels of urine albumin and plasma NPY were de- creased greatly （P〈0.05）, and the extent in experimental group was greater than that in control group （P〈0.05）. Conclusion Sim- vastatin has a significant role in reducing plasma NPY and urine albumin concentration in type 2 diabetic nephropathy, and may help to slow down the process of diabetic nephropathy.