慢性肾衰竭患者血清铝负荷及相关因素分析

目的：探讨慢性肾衰竭患者血清铝水平的变化及其影响因素。方法收集530例慢性肾衰竭患者与262例健康体检者血清标本，采用石墨炉原子吸收光谱法测定血清中铝含量。对所得数据和资料进行统计学处理，多元线性回归筛选分析慢性肾衰竭患者血清铝的影响因素。结果慢性肾衰竭患者血清铝水平为17.33±3.15μg/L，显著高于正常人血清铝水平1.57±0.45μg/L（P〈0.001）；慢性肾衰竭患者血清铝水平与性别、体重、身高、血压、饮食中肉食所占的比例无显著相关，与尿量周透析次数成负相关，与年龄、使用维生素D（VitD）、红细胞生成素（EPO）和磷结合剂、近期接受输血、透析次数成正相关，与透析方式显著相关。结论慢性肾衰竭患者铝负荷较高，肾功能下降、饮食习惯、治疗措施及透析情况影响患者血清铝水平。

Analysis of serum aluminum level and its correlative factors in patients with chronic renal failure

Objective To explore the change of serum aluminum level and its influence factors in patients with chronic renal failure. Methods Serum aluminum were determined by graphite furnace atomic absorption spectrometer in 530 patients with chronic renal failure and 262 healthy people. The data were analyzed statistically by multivariate linear regression analysis. Re-sults The level of serum aluminum in patients with chronic renal failure was 17.33 ±3.15μg/L, which was significantly higher than that （1.57±0.45μg/L） in healthy people （P〈0.05）. The level of serum aluminum was negatively related to urine volume and positively related to application of VitD, EPO, phosphate binder,blood transfusion, the methods and times of dialysis, but not to patients＆#39; gender, weight, height, blood pressure and dialysis status. Conclusion The level of serum aluminum in patients with chronic renal failure is high. Failure of renal function is the primary influence factor of aluminum overload, which is also con-tributed by diet, treatment and dialysis condition.