| 不同抗凝剂对肝移植受者FK506血药浓度测定的影响及临床意义 |
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| 引用本文： | 胡翠华,乔江春,马嵘,刘桂芹,谢洁红,张传宝,郭健.不同抗凝剂对肝移植受者FK506血药浓度测定的影响及临床意义[J].上海医学检验杂志,2010(5). |
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| 作者姓名： | 胡翠华 乔江春 马嵘 刘桂芹 谢洁红 张传宝 郭健 |
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| 作者单位： | 卫生部北京医院卫生部临床检验中心;卫生部北京医院外科;卫生部北京医院病案室; |
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| 摘 要： | 目的探讨不同抗凝剂对肝移植受者他克莫司(FK506)血药浓度测定的影响及临床意义。方法采集肝移植受者静脉全血34份,使用乙二胺四乙酸二钾(EDTA-K2)、枸橼酸钠和肝素锂抗凝剂分别抗凝同一份血样本,在IMx型免疫分析仪上用微粒子酶免疫分析法(MEIA)测定FK506血药浓度。结果肝素锂组与EDTA组差异无统计学意义(P=0.660),呈正相关(r=0.982 8)。枸橼酸钠组与EDTA组差异有统计学意义(P=0.000),呈正相关(r=0.961 3)。枸橼酸钠组与肝素锂组差异有统计学意义(P=0.000),呈正相关(r=0.939 8)。结论肝素锂组与EDTA组几乎无偏差,但是枸橼酸钠组分别与EDTA组和肝素锂组存在一定程度的负偏差。枸橼酸钠对MEIA测定FK506血药浓度有一定的影响,应优先考虑EDTA或肝素锂抗凝剂采集全血样本。
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| 关 键 词： | 抗凝剂 他克莫司 肝移植受者 微粒子酶免疫分析法 |
The effect of different anticoagulants on determination of FK506 blood concentration in liver transplant recipients and clinical significance |
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| HU Cuihua,QIAO Jiangchun,MA Rong,LIU Guiqin,XIE Jiehong,ZHANG Chuanbao,GUO Jian..The effect of different anticoagulants on determination of FK506 blood concentration in liver transplant recipients and clinical significance[J].Shanghai Journal of Medical Laboratory Sciences,2010(5). |
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| Authors: | HU Cuihua QIAO Jiangchun MA Rong LIU Guiqin XIE Jiehong ZHANG Chuanbao GUO Jian |
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| Institution: | HU Cuihua1,QIAO Jiangchun2,MA Rong1,LIU Guiqin3,XIE Jiehong1,ZHANG Chuanbao1,GUO Jian1.(1.National Center for Clinical Laboratory,Beijing Hospital Ministry of Health,Beijing 100730,China,2.Department of Surgery,3.Department of Case History,China) |
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| Abstract: | Objective To investigate the effect of different anticoagulants on determination of tacrolimus(FK506) blood concentration in liver transplant recipients and clinical significance.Methods 34 venous whole blood specimens from liver transplant recipients were collected simultaneously via various anticoagulants of ethylenediamine tetraacetic acid dipotassium(EDTA-K_2),sodium citrate and lithium heparin.FK506 whole blood concentrations were measured by microparticle enzyme immunoassay(MEIA) on IMx immunoassay an... |
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| Keywords: | Anticoagulant Tacrolimus Liver transplant recipient Microparticle enzyme immunoassay |
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