中药复方排毒养生胶囊临床戒毒研究

目的:观察中药排毒养生胶囊对海洛因依赖临床脱毒治疗效果。方法:海洛因依赖患者580例,随机分为排毒养生胶囊治疗组302例、美沙酮对照组278例;采用《阿片类药物依赖戒断症状量表》(OWS)、焦虑量表(HAMA)评定疗效。结果:治疗d1～d4,治疗组戒断症状完全控制率>80%,d5以后完全控制率达100%;总控制水平稍低于美沙酮对照组,但两组之间无显著性差异(P>0.05)。结论:中药排毒养生胶囊对海洛因成瘾临床脱毒治疗效果较满意,与常模戒毒药物美沙酮疗效相近,且临床接受率和依从性好,使用安全。

Controlled Clinical Study on Paiduyangsheng Capsule in Detoxification of Heroin Abuse

Objective: To observe the detoxification efficacy of Paiduyangsheng capsule (PYC), a TCM drug in heroin addicts clinically. Methods: 580 heroin addicts under detoxification were randomly divided into two groups: 302 cases were included into PYC group, as experimental; and other 278 cases into methadone group, as control. Using the scales OWS and HAWA, their efficacy of decreasing abstinence symptoms and improving anxiety was evaluated. Results: For experimental group in d 1- d 4 the complete control rate was >80%, and in d5 it reached 100%. It means that the total control level of experimental group was slightly lower than the control without significant difference (P > 0.05). Conclusion: The efficacy of detoxification of PYC as a TCM drug is satisfactory, approaching to efficacy of control i.e. methadone group; moreover, PYC is acceptable and safe in clinic.