西酞普兰单用与西酞普兰与齐拉西酮合用治疗抑郁症的疗效对比观察

目的探讨西酞普兰与齐拉西酮合用治疗伴躯体症状抑郁症的疗效。方法将46例伴躯体障碍的抑郁症患者随机分为单用西酞普兰组和西酞普兰与齐拉西酮合用组，进行8周的治疗，采用汉密顿抑郁量表（HAMD）、副反应量表（TESS）和自编躯体症状调查表进行测评。结果在抑郁症缓解方面两组均显效；对于躯体症状的改善，合并组优于单用组。两组副作用均较小。结论西酞普兰与齐拉西酮合用治疗伴躯体障碍抑郁症效果优于单用西酞普兰。

Comparative Observation of the Curative Effect of Citalopram Only and Citalopram Combined with Ziprasidone in Treating Depression

Objective To study the curative effect of citalopram combined with ziprasidone in treating depression with somatic symptoms. Methods 46 cases with depression and somatic obstacles were randomly divided into 2 groups ： the single group （ having citalopram only ） and the combined group （ have citalopram combined with ziprasidone ） ; after the treatment for 8 weeks, HAMD Scale, Treatment Emergent Symptom Scale （TESS） and the self - designed somatic symptom questionnaire were applied to make the survey. Results Both groups showed excellence of depression relief while the improvement of somatic symptom in the combined group was superior to that in the single group ; both groups showed out less side effect. Conclusions The curative effect of citalopram combined with ziprasidone is superior to that of citalopram only in treating depression with somatic obstacles.