| 新生小鼠小脑提取液对成年小鼠神经干细胞分裂与增殖的影响 |
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| 引用本文： | 罗焕敏,高勤,肖飞,章佩芬,翁文,李晓光,蒋光愉.新生小鼠小脑提取液对成年小鼠神经干细胞分裂与增殖的影响[J].中国新药杂志,2004,13(3):230-232. |
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| 作者姓名： | 罗焕敏 高勤 肖飞 章佩芬 翁文 李晓光 蒋光愉 |
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| 作者单位： | 1. 暨南大学药学院神经药理研究室,广州,510632
2. 暨南大学第一附属医院病理科,广州,510630 |
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| 摘 要： | 目的:探讨新生小鼠小脑提取液(ECNM)对成年小鼠脑内神经干细胞分裂与增殖的影响.方法:采用脑立体定位给药技术,将ECNM注入前脑和海马,应用Nestin单抗做免疫组化染色,显示神经干细胞.结果:给予ECNM后7d和14d,在前脑和海马均可见密集的神经干细胞,对照组未见阳性染色.结论:ECNM可诱导成年小鼠神经干细胞分裂与增殖.
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| 关 键 词： | 新生小鼠小脑提取液(ECNM) 神经干细胞 分裂 增殖 巢蛋白 |
| 文章编号： | 1003-3734(2004)03-0230-03 |
Effect of ECNM (extract of cerebellum of newborn mouse) on division and proliferation of neural stem cell in adult mouse brain |
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| LUO Huan-min,GAO Qin,XIAO Fei,ZHANG Pei-fen,WENG Wen,LI Xiao-guang JIANG Guang-yu.Effect of ECNM (extract of cerebellum of newborn mouse) on division and proliferation of neural stem cell in adult mouse brain[J].Chinese Journal of New Drugs,2004,13(3):230-232. |
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| Authors: | LUO Huan-min GAO Qin XIAO Fei ZHANG Pei-fen WENG Wen LI Xiao-guang JIANG Guang-yu |
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| Abstract: | Objective:To investigate the effects of ECNM on division and proliferation of neural stem cells in adult mice brain. Methods:Brain stereotactic technology was used to deliver ECNM into forebrain and hippocampus, and monoclonal antibody to nestin was used for immunohistochemical staining to display neural stem cells.Results:7 and 14 days after injecting ECNM,massed neural stem cells were observed at forebrain and hippocampus but not observed in control group. Conclusion: The division and proliferation of neural stem cells of adult mice can be induced by ECNM. |
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| Keywords: | extract of cerebellum of newborn mouse(ECNM) neural stem cell division proliferation nestin |
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