| 参芪桂苷汤对异丙肾上腺素致大鼠心肌损伤的保护作用 |
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| 引用本文： | 陈玲,涂春香,黄海. 参芪桂苷汤对异丙肾上腺素致大鼠心肌损伤的保护作用[J]. 福建中医学院学报, 2006, 16(5): 35-36,62 |
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| 作者姓名： | 陈玲 涂春香 黄海 |
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| 作者单位： | 1. 福建中医学院中西医结合系,福建,福州,350108
2. 福建中医学院中医系,福建,福州,350108 |
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| 摘 要： | 为探讨参芪桂苷汤对异丙肾上腺素致大鼠心肌损伤的保护作用，采用皮下注射30mg／kg异丙肾上腺素造成Wistar大鼠心肌缺血性损伤模型，30只大鼠随机分为正常对照组、缺血模型组、参芪桂苷汤组，观察心电图、心肌病理、血清磷酸肌酸激酶（CPK）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）、脂质过氧化物丙二（MDA）含量的变化，结果发现参芪桂苷汤组可显著降低异丙肾上腺素所致心肌缺血大鼠的心电图异常升高的ST段，使血清CPK、LDH降低，增加心肌组织SOD的活力，减少MDA生成，与模型组比较，P〈0．05，说明参芪桂苷汤对大鼠心肌损伤有保护作用。
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| 关 键 词： | 参芪桂苷汤 异丙肾上腺素 模型大鼠 超氧化物歧化酶 过氧化脂质类 |
| 文章编号： | 1004-5627（2006）05-0035-02 |
| 收稿时间： | 2006-06-10 |
| 修稿时间： | 2006-06-10 |
Protective Effect of Shenqi Guigan Decoction on Myocardial Injury Rats Induced by Isoproterenol |
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| CHEN Ling,TU Chun-Xiang,HUANG Hai. Protective Effect of Shenqi Guigan Decoction on Myocardial Injury Rats Induced by Isoproterenol[J]. Journal of Fujian College of Traditional Chinese Medicine, 2006, 16(5): 35-36,62 |
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| Authors: | CHEN Ling TU Chun-Xiang HUANG Hai |
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| Affiliation: | 1. Department of integrative medicine, FCTCM, Fuzhou, Fujian 350108, China; 2. Department of TCM, FCTCM, Fuzhou, Fujian 350108, China |
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| Abstract: | To study the protective effect of shenqi guigan decoction on myocardial injury rats induced by isoproterenol(ISO).Thirty Wistar rats were randomly divided into three groups(control group,model group and shenqi guigan decoction treatment group),the last two groups were given subcutaneous injection of ISO(30mg/kg) to induce myocardial injury.The electrocardiogram,the pathological changes on myocardium,the levels of CPK and LDH in serum,SOD and MDA on myocardium of three groups were detected.The results showed that shenqi guigan decoction could markedly decrease abnormal ST segment elevation in myocardial injury rats induced by ISO,reduce the levels of CPK and LDH,increase the activity of SOD,and reduce the production of MDA,there was significant difference between the last groups(P<0.05).Conclusion: Shenqi guigan decoction has the protective effects on myocardial injury rats. |
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| Keywords: | shenqi guigan decoction isoproterenol rat SOD MDA |
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