| 绞股蓝在大鼠肝的抗脂质过氧化作用 |
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| 引用本文： | 陶建武,姚彩萍,王冀春,郝广丽,叶正君.绞股蓝在大鼠肝的抗脂质过氧化作用[J].中国临床药学杂志,2001,10(3):160-162. |
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| 作者姓名： | 陶建武 姚彩萍 王冀春 郝广丽 叶正君 |
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| 作者单位： | 湖北药检高等专科学校实验中心 |
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| 摘 要： | 目的：观察绞股蓝（GP）对四氯化碳（CCl4)所致肝脏脂质过氧化的干预作用。方法：将Wistar大鼠随机分为4组：A（对照组）；B（CCL4）；C（GP);D(CCL4＋CP）。结果：CCL4组的脂质过氧化物（LPO）含量明显高于对照组，谷胱甘肽过氧化物酶（GSH－Px）活性低于对照组；而同时给予GP的D组可减弱CCL4诱发的上述作用。结论：GP能减弱CCL4对肝脏的损害。
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| 关 键 词： | 绞股蓝 脂质过氧化物 谷胱甘肽过氧化物酶 药理学 GP |
| 文章编号： | 1007-4406(2001)03-0160-03 |
Inhibitory effects of gynostemma pentaphyllum on lipid peroxidation reaction in rats liver |
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| Tao Jianwu,Yao Caiping,Wang Jichun,Hao Guangli,Ye Zhengjun.Inhibitory effects of gynostemma pentaphyllum on lipid peroxidation reaction in rats liver[J].Chinese Journal of Clinical Pharmacy,2001,10(3):160-162. |
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| Authors: | Tao Jianwu Yao Caiping Wang Jichun Hao Guangli Ye Zhengjun |
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| Abstract: | AIM: To observe inhibitory effects of gynostemma pentaphyllum (GP) on liver lipid peroxidation caused by carbon tetrachloride (CCl 4). METHODS: Wistar rats were randomly divided into 4 groups: A (control); B (CCl 4); C (GP); D (CCl 4+GP). RESULTS: The content of lipid peroxide (LPO) increased and the vitality of glutathione peroxidase (GSH Px) decreased in CCl 4 group compared with the control group. The lipid peroxidation caused by CCl 4 was inhibited by administering GP simultaneously. CONCLUSION: The results indicate that GP could decrease liver injury induced by CCl 4. |
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| Keywords: | gynostemma pentaphyllum lipid peroxidation reaction glutathione peroxidase |
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