| 酚-黄复方微乳的体外透皮特性考察 |
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| 引用本文： | 邓新焕,王亚静,于悦,孟亚飞,任树龙. 酚-黄复方微乳的体外透皮特性考察[J]. 中国实验方剂学杂志, 2014, 20(21): 5-8 |
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| 作者姓名： | 邓新焕 王亚静 于悦 孟亚飞 任树龙 |
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| 作者单位： | 天津中医药大学 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学 现代中药发现与制剂技术教育部工程研究中心, 天津 300193 |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2012ZX09304007) |
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| 摘 要： | 目的:制备酚-黄复方微乳并考察其体外透皮扩散特性。方法:以油酸乙酯为油相,聚山梨酯-80(tween-80)为乳化剂,聚乙二醇-400(PEG-400)为助乳化剂,水相逐步加入到含药混合溶液中,制备酚-黄复方微乳。测定微乳的外观形态、粒径分布及稳定性。采用Franze扩散池法,考察补骨脂酚、黄芩苷在溶液和微乳中经皮渗透特性。结果:制备的微乳澄清透明,呈近球形,平均粒径(17.30±0.17)nm,稳定性较好。黄芩苷在溶液和微乳中24 h累积透过量(Q24 h)分别为(208.80±5.26),(232.38±15.07)μg·cm-2,经皮渗透特性无显著性差异。补骨脂酚24 h累积透过量由溶液中(324.81±56.63)μg·cm-2增加至微乳中的(721.30±108.88)μg·cm-2,增加了2.22倍,稳态渗透速率和表观渗透系数为溶液组的5.0倍,均有显著提高。结论:微乳经皮给药系统具有很好的促透作用,为酚-黄复方皮肤给药新制剂的设计提供实验依据。
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| 关 键 词： | 补骨脂酚 黄芩苷 酚-黄复方微乳 经皮渗透特性 表观渗透系数 稳态渗透速率 |
| 收稿时间： | 2014-03-26 |
Investigation of in vitro Transdermal Properties of Bakuchiol-baicalin Compound Microemulsions |
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| DENG Xin-huan,WANG Ya-jing,YU Yue,MENG Ya-fei and REN Shu-long. Investigation of in vitro Transdermal Properties of Bakuchiol-baicalin Compound Microemulsions[J]. China Journal of Experimental Traditional Medical Formulae, 2014, 20(21): 5-8 |
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| Authors: | DENG Xin-huan WANG Ya-jing YU Yue MENG Ya-fei REN Shu-long |
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| Affiliation: | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | bakuchiol baicalin bakuchiol-baicalin compound microemulsions percutaneous penetration characteristics apparent permeability coefficient steady-state infiltration rate |
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