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The C523A β2 Adrenergic Receptor Polymorphism Associates with Markers of Asthma Severity in African Americans
Authors:John J. Lima   Janet T. Holbrook  Jianwei Wang  James E. Sylvester  Kathryn V. Blake  Malcolm N. Blumenthal  Mario Castro  Nicholas Hanania  Robert Wise
Affiliation: a The American Lung Association Asthma Clinical Research Centers, Nemours Children's Clinic, Jacksonville, Florida, USAb Nemours Children's Clinic, Pharmacogenetics Center, Nemours Children's Clinic, Jacksonville, Florida, USAc The Johns Hopkins University, Baltimore, Maryland, USA
Abstract:Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively (p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.
Keywords:β2 adrenergic receptor  polymorphisms  asthma severity  race
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