Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings |
| |
Authors: | Stern David Yan Shi Du Yan Shi Fang Schmidt Ann Marie |
| |
Affiliation: | Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. dstern@mail.mcg.edu |
| |
Abstract: | Receptor for Advanced Glycation Endproducts (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules capable of interacting with a broad spectrum of ligands, including advanced glycation endproducts (AGEs), amyloid fibrils, S100/calgranulins and amphoterin. The biology of RAGE is dictated by the accumulation of these ligands at pathologic sites, leading to upregulation of the receptor and sustained RAGE-dependent cell activation eventuating in cellular dysfunction. Although RAGE is not central to the initial pathogenesis of disorders in which it ultimately appears to be involved, such as diabetes, amyloidoses, inflammatory conditions and tumors (each of these conditions leading to accumulation of RAGE ligands), the receptor functions as a progression factor driving cellular dysfunction and exaggerating the host response towards tissue destruction, rather than restitution of homeostasis. These observations suggest that RAGE might represent a therapeutic target in a diverse group of seemingly unrelated disorders linked only by a multiligand receptor with an unusually wide and diverse repertoire of ligands, namely, RAGE. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|