肾衰颗粒对慢性肾衰竭患者血浆内皮素、一氧化氮的影响

目的：观察肾衰颗粒对慢性肾功能衰竭患者的血浆内皮素（ET）、一氧化氮（NO）的影响及疗效。方法：60例慢性肾功能衰竭患者随机分为2组，治疗组30例口服肾衰颗粒，对照组30例口服包醛氧淀粉，观察2组血尿素氮（BUN）、血肌酐（SCr）、肌酐清除率（Ccr）、血浆内皮素（ET）、一氧化氮（NO）的变化。结果：治疗组BUN、Cr下降明显（P〈0．01），Ccr升高明显（P〈0．01），与阳性对照组比无差异；ET下降明显（P〈0．01），NO升高明显（P〈0．01），且均优于阳性对照组（P〈0．05，P〈0．01）。结论：肾衰颗粒能延缓慢性肾功能衰竭的进展。

The Effect of Shen Shuai KeLi on Endothelin and Nitric Monoxide in Patients with Chronic Renal Failure

Objective:To observe the effect of Shen Shuai KeLi on endothelin(ET) and nitrogen monoxide(NO)of chronic renal failure(CRF).Method:60 patients with CRF were randomly divided into two groups.30 patients in treatment group were treated with ShenShuai KeLi;the other 30 patients in control group were treated with oxyamyli tectus aldehydum.The blood urea nitrogen(BUN),serum creatinins(Scr),NO,ET and creatinine clearance rate(Ccr) were detected in both groups.Results:Compared with those in control group,the BUN,Cr,ET in treatment group decreased significantly(P<0.01),and the NO,Ccr in treatment group increased significantly(P<0.01).Conclusion:ShenShuai KeLi can decrease the BUN,ET,and Scr and increase NO and Ccr in patients with chronic renal failure,so it may delay the progress of chronic renal failure.