In vivo identification and monitoring of changes in rat brain glucose by two-dimensional shift-correlated 1H NMR spectroscopy. |
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| Authors: | M Peres O Fedeli B Barrere B Gillet G Berenger J Seylaz J C Beloeil |
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| Affiliation: | Institut de Chimie des Substances Naturelles C.N.R.S., Gif sur Yvette, France. |
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| Abstract: | Intracerebral glucose resonance was directly detected and resolved in vivo by two-dimensional shift-correlated (COSY) 1H NMR spectroscopy in anesthetized rats (n = 4). The relative changes in brain glucose concentration were measured by volume integration of the alpha-D-glucose cross peak in the 2D COSY spectra. This report demonstrates the possibility of monitoring the variations in cerebral glucose following iv injection of glucose. |
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