Captive solvent [11C]acetate synthesis in GMP conditions. |
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| Authors: | Dmitri Soloviev Claire Tamburella |
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| Institution: | 1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA;2. Eli Lilly & Co., Indianapolis, IN, USA |
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| Abstract: | Reliable procedure for the production of 1-(11)C]acetate in GMP conditions was developed based on a combination of the captive-solvent Grignard reaction conducted in the sterile catheter followed by the convenient solid-phase extraction purification on a series of ion-exchange cartridges. The described procedure proved to be reliable in more than 30 patient productions. The process provides stable radiochemical yields (65% EOB) of sodium acetate (1-(11)C]) of the Ph.Eur. quality (radiochemical purity better than 95%) in a short time (5 min). |
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