血清胃蛋白酶原1、2在胃癌诊断中的价值

目的 探讨血清胃蛋白酶原（PG）检测对胃癌诊断价值.方法 采用胶乳增强免疫比浊法对36例非萎缩性胃炎、39例胃溃疡、31例萎缩性胃炎及42例胃癌患者血清PG1、PG2水平进行了检测.结果 非萎缩性胃炎组、胃溃疡组、萎缩性胃炎组及胃癌组中血清PG1水平及PG1/ PG2比值（PGR）逐渐降低,以胃癌组降低最为明显,显著低于其他三组患者（P〈0.01）,胃溃疡组血清PG2水平显著高于其他三组（P〈0.01）,其他三组血清PG2水平无统计学差异（P〉0.05）,以PG1〈70 μg/L,且PGR〈3.0为判断界值,其诊断胃癌的敏感性为78.6%,特异性为85.8%.结论 血清PG1及PGR明显降低可作为胃癌及癌前病变的一项血清学诊断指标,对于提高胃癌早期诊断率和早期治疗率,从而降低病死率具有积极意义.

Clinical value of serum pepsinogen levels in diagnosis of gastric cancer

Objectivc To study the diagnosis valve of serum pepsinogen（PG） in gastric cancer patients. Methods Using immu- noturbidimetry method, the serum pepsinogen levels of 36 non-atrophic gastritis patients, 39 gastric ulcer patients, 31 atrophic gas- tritis patients and 42 gastric cancer patients were detected. Results The serum PG1 levels and PG1/PG2 ratio（PGR） decrease gradually in non-atrophic gastritis, gastric ulcer, atrophic gastritis than the other three groups（P〈0.01）. The serum PG2 levels in and gastric cancer, gastric cancer groups were significant lower gastric ulcer group were significant higher than the other three groups（P〈0.01）, while there was no statistically significant difference between the other three groups （P〉 0.05 ）, with PG1 〈 70 μg/L besides PGR〈3.0 as the judgement valve,the diagnositic sensitivity and specificity in gastric cancer were 78.6% and 85.8% respectivly. Conclusion The serum pepsinogen levels and PGR can be used as one serum diadynamie criteria to gastric cancer and precancerosis,and has significant value in raise the early diagnosis and treatment rate,and accordingly degrade the death rate.