亚临床甲状腺功能减退症患者血脂与同型半胱氨酸的代谢特点

目的 研究亚临床甲状腺功能减退症患者血脂、同型半胱氨酸（HCY）的代谢特点.方法 亚甲减患者92例,甲减患者34例,对照者57例,分别检测血总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）与HCY的水平并作比较.结果 亚甲减组的TC、LDL-C、HCY水平明显高于对照组（P〈0.01）,与甲减组差异也有统计学意义（P〈0.05）.亚甲减患者治疗后促甲状腺激素（TSH）、TC、HCY、LDL-C与治疗前相比显著降低（P〈0.01）,而TG、HDL-C无显著性差异（P〉0.05）.超敏促甲状腺激素（HS-TSH）与TC、LDL-C、HCY呈正相关.结论 亚临床甲减是脂代谢异常及高HCY血症的高危因素之一,特别当HS-TSH≥10 mU/L,亚甲减患者应积极考虑替代治疗.

The metabolic characteristics of lipid profile and homocysteine in the patients with subclinical hypothyroidism

Objective To study metabolic characteristics of lipid profile and homocysteine in the patients with subclinical hypot- hyroidism（SCH）. Methods 92 patients with SCH,34 patients with hypothyroidism and 57 control subjects were recruited in the study. Serum HS-TSH,TC,TG, LDL-C, HDL-C and HCY were measured and compared. Results The levels of TC, LDL-C and HCY were higher in patients with SCH than the control subjects（P〈0.01）. The levels of TC, LDL-C and HCY had significant differences between patients with SCH and patients with hypothyroidism（P〈0.05）. After treatment,The levels of TSH ,TC, HCY and LDL-C were significantly decreased, except TG and HDL-C. HS-TSH was positively correlated with TC, LDL-C and HCY. Conclusion SCH was a risk factor of abnormal lipid metabolism and hyperhomocystinemia.