127株阴沟肠杆菌耐药性监测分析

目的 了解该院临床分离的阴沟肠杆菌的分布与耐药性的特点,以便更好地指导临床用药.方法 用VITEK-2 COMPACT全自动分析系统（法国生物梅里埃公司）进行菌株鉴定和药敏试验.结果 127株阴沟肠杆菌主要来源于伤口分泌物（47.24%）、痰液（34.65%）、中段尿（6.30%）,药敏结果显示阴沟肠杆菌对氨苄西林、氨苄西林/舒巴坦、呋喃妥因、头孢替坦、头孢唑啉的耐药率均高达90%以上,对亚胺培南耐药率仅为1.57%,显示出高敏感性.结论 阴沟肠杆菌耐药性增加,出现了对碳青霉烯类抗菌药物不敏感菌株,建议临床应根据药物敏感试验结果合理使用抗菌药物,减少耐药菌株的产生.

Analysis of drug resistance of 127 Enterobactter cloacae isolated strains

Objective To investigate the characteristics of distribution and antimicrobial resistance of Enterobacter cloacae iso- lates in the hospital, so as to guide clinical treatment. Methods VITEK-2 COMPACT automatic analysis system was uesed for strain identification and drug sensitive test. Results 127 strains of Enterobacter cloacae were isolated mainly from wound secretion （47.24 % ）, sputum（34.65 %）, and urine（6.30 %）. The results of drug sensitivity showed Enterobacter cloacae had high resistance to ampicillin,ampicillin/sulbactam,nitrofurantin, and zygosaccharomyces cefotetan, and the rates of drug resistance were all higher than 90%. However,Enterobaeter cloacae showed high sensibility to imipenem with the resistant rate only 1.57%. Conclusion In- creasing drug resistance of Enterobacter cloacae and the emergence of the carbapenem antibiotics resistant strain suggest that rec- ommendations for clinical rational use of antibiotics should be based on the results of drug sensitive test.