冠心病的基因治疗

冠心病是严重威胁人类生命和健康的常见疾病。虽然冠状动脉旁路移植术和血管内介入治疗已经得到充分发展，但仍有一部分严重冠心病患者不能得到有效的治疗。近年来，冠心病的基因治疗成为研究的热点。本文从以下几方面对冠心病基因治疗的研究进展进行简要介绍；目的基因的选择，基因载体的选择和心脏基因导入途径的选择。对于血管内皮生长因子基因，成纤维细胞生长因子基因，肝细胞生长因子基因和促血管生成素－1基因在冠心病治疗中应用的实验和研究现状提供了重点介绍。

Gene therapy for coronary heart disease

Coronary artery bypass surgery and angioplasty provide symptomatic relief in patients with ischemic heart disease, but despite advancement in technique and devices, these methods are not applicable to a subset of patients with angina refractory to medical treatment. Recently, attention has been focused upon novel approaches using gene based therapy to treat coronary heart disease. This article briefly introduces the development in gene therapy of coronary heart disease including favorable therapeutic genes, vectors for gene therapy and techniques for delivering genes into the heart. We focus on the available experimental and clinical experiences with the treatment of myocardial ischemia using genes encoding for different growth factors such as vascular endothelial growth factor, fibroblast growth factor, hepatocyte growth factor and angiopoietin 1.