地佐辛与吗啡用于结肠癌根治手术后硬膜外镇痛的比较

目的观察地佐辛用于结肠癌根治手术后硬膜外镇痛效果。方法 60例结肠癌根治手术患者随机分为两组,(D组)地佐辛5mg+1%罗派卡因10mL+生理盐水至100mL,(M组)吗啡5mg+1%罗派卡因10mL+生理盐水至100mL。观察2组患者48h VAS镇痛评分、自控镇痛次数、不良反应发生率。结果两组镇痛评分、自控镇痛次数对照无统计学差异(P>0.05),地佐辛组不良反应发生率低于吗啡组(P<0.05),差异有统计学意义。结论地佐辛(0.005%)应用于椎管内术后镇痛,其镇痛效果与同等剂量(0.005%)吗啡相当,而不良反应如呕吐,皮肤瘙痒,呼吸抑制少于吗啡。

Effects of Dezocine on Epidural Analgesia after Radical Resection for Colon Cancer

Objective To investigate the effects of Dezocine on epidural analgesia after radical resection for colon cancer.Methods 60 patients with radical resection for colon cancer were randomly divided into two groups： Dezocine group（group D） and morphine group（group M）;group D： Dezocine 5mg ＋1% Ropivacaine 10mL add saline to 100mL,（M group）;group M： morphine 5mg ＋1% Ropivacaine 10mL add saline to 100mL.Recoreds the VAS pain score（48h）,PCA times and the incidence of adverse reactions.Results There were no statistical significance of the VAS pain score（48h）.PCA times（P0.05）,compared with Group M,the incidence of adverse reactions were significantly decreased in group D（P0.05）.Conclusion Dezocine（0.005%） can be used for epidural analgesia after surgery,the analgesic function with the same dose（0.005%） of morphine equivalent.compared with group M,the incidence of adverse reactions in group D such as vomiting,pruritus,respiratory depression were significantly decreased.